GPBAR1-mediated bile acid sensing in cholangiocytes drives IL-23/Th17-dependent inflammation in PSC
收藏NIAID Data Ecosystem2026-05-10 收录
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https://data.mendeley.com/datasets/jt5zfwshm3
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资源简介：
Primary sclerosing cholangitis (PSC) is a progressive cholangiopathy characterized by bile duct inflammation, fibrosis, and increased risk of cholangiocarcinoma. Here we identify the IL-23/IL-17 axis as a central amplifier of PSC and demonstrate that PBT002, an hybrid dual GPBAR1/RORγt ligand, restores immune and metabolic balance in preclinical models.
创建时间：
2025-11-07
