Cell type distribution in female and male mouse brains / Calb1_GFP_F8_201009

This project proposes to establish an Anatomical Collaboratory for Systematic Atlasing of Cell-Type Distribution and Morphology in female and male brain. This Collaboratory will apply standardized, unbiased and largely automated methods developed in the group’s laboratories to atlas the distribution and morphology of >80 molecularly defined cell classes and cell type across all regions of the female and male brain. This work will yield the most comprehensive characterization of cell type anatomy in the mammalian brain to date, establishing a structural basis for building an integrated Cell Type Brain Atlas.

本项目拟搭建解剖学协作平台（Anatomical Collaboratory），用于系统绘制雌雄大脑的细胞类型分布与形态图谱。该协作平台将采用本团队实验室开发的标准化、无偏倚且高度自动化的研究方法，对雌雄大脑全脑区域内逾80种经分子层面定义的细胞类群与细胞类型的分布及形态进行图谱绘制。本研究将产出迄今为止针对哺乳动物大脑细胞类型解剖学特征的最全面表征，为构建整合式细胞类型大脑图谱（Cell Type Brain Atlas）奠定结构基础。