The main characteristics of included studies regarding the association between the GNB3 C825T polymorphism and hypertension.

HT, hypertension; SOC, source of control; PB, population-based, controls were blood donors, healthy controls matched for age, gender and domicile and participants in an health service programme from the same geographical region without clinically detectable hypertension; HB, hospital-based, controls were patients admitted to hospital without hypertension matched for age, gender and domicile; HWE, Hardy–Weinberg equilibrium; and MAF, minor allele frequency; Three publications [26]–[28] contained more than one independent population, therefore, we considered them as different studies. Two studies [57], [80] were limited to the relationship in males. The samples [54], [75] were from individuals of African descent.HT：高血压（hypertension）；SOC：对照来源（source of control）；PB：基于人群的对照（population-based，对照为献血者、年龄、性别与居住地匹配的健康对照，以及来自同一地理区域、无临床可检测高血压的健康服务项目参与者）；HB：基于医院的对照（hospital-based，对照为无高血压且年龄、性别、居住地匹配的住院患者）；HWE：哈迪-温伯格平衡（Hardy–Weinberg equilibrium）；MAF：次要等位基因频率（minor allele frequency）。三篇文献[26]–[28]包含多个独立研究人群，故将其视为不同的研究。两项研究[57]、[80]仅聚焦于男性群体中的关联分析。样本[54]、[75]均来自非洲裔人群。