The influence of WWOX gene on cellular pathways in neuronal differentiation of human neural stem cells. The influence of WWOX gene on cellular pathways in neuronal differentiation of human neural stem cells

The aim of presented study was to investigate in detail how depletion of WWOX gene disturbs signaling pathways pivotal in neuronal differentiation and CNS organogenesis. We conducted a global transcriptome analysis using CAGE method. Overall design: Human neural stem cells (H9 hESC-Derived, Gibco, cat. No. N7800-100) with native and silenced (by shRNA lentiviral system) WWOX expression were compared before and after differentiation into neurons.