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Emergent metastatic heterogeneity of primary tumor cells is restricted by the Ig-transmembrane protein VSIG V

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NIAID Data Ecosystem2026-03-12 收录
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Our study prompeted us to assign, through spiked single cell RNAseq, metastatic function to transcriptomic cluster of colon cancer cells. Interactions between clones also uncover a restrictive anti metastatic influence that act intrinsically and non-cell automomously. We identify VSIG1 as critical mediator of this influence. Overall design: RNAseq of clone E3 infected with lentivirus for ectopic expression of VSIG1V1 and VSIGV2 cDNA and PTWEEN

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2020-11-09
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