Cryo-EM structure of human organic solute transporter Ost-alpha/beta bound with DHEAS

Cryo-EM structure of human organic solute transporter Ost-alpha/beta bound with DHEAS Descriptor: (7E,21R,24S)-27-amino-24-hydroxy-18,24-dioxo-19,23,25-trioxa-24lambda~5~-phosphaheptacos-7-en-21-yl (9Z,12E)-octadeca-9,12-dienoate, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 17-oxoandrost-5-en-3beta-yl hydrogen sulfate, ... Authors: Yang, X, Xu, E. Deposit date: 2025-04-24 Release date: 2025-12-10 Last modified: 2026-03-18 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Structures of Ost alpha / beta reveal a unique fold and bile acid transport mechanism. Nature, 651, 2026人类有机溶质转运蛋白Ost-α/β结合硫酸脱氢表雄酮（DHEAS）的冷冻电镜（Cryo-EM）结构。描述物：(7E,21R,24S)-27-氨基-24-羟基-18,24-二氧代-19,23,25-三氧杂-24λ⁵-磷杂二十七碳-7-烯-21-基(9Z,12E)-十八碳-9,12-二烯酸酯、1-O-十八烷基-SN-甘油-3-磷酸胆碱、17-氧代雄甾-5-烯-3β-基硫酸氢酯等。作者：Yang, X、Xu, E. 保藏日期：2025-04-24；发布日期：2025-12-10；最后修改日期：2026-03-18。实验方法：电子显微镜（2.9 Å）。引用文献：《Ost α/β的结构揭示独特折叠模式与胆汁酸转运机制》，《自然》，第651卷，2026年。