The phenotypic consequences of individual mutations are modulated by the wild-type genetic background in which they occur. Although such background dependence is widely observed, we do not know whethe
Legends for Supplemental Figures S1-S4 are provided within the figures themselves. Movie S1. Movement of Vezl:Venus within axons. Four short movies (spiced together) of Vezl:Venus imaged i
Meiotic silencing by unpaired DNA (MSUD) was discovered in crosses made in the standard Oak Ridge (OR) genetic background of Neurospora crassa. However, MSUD often was decidedly less efficient when th
Prion diseases include a number of progressive neuropathies involving conformational changes in cellular prion protein (PrPc) that may be fatal sporadic, familial or infectious. Pathological evidence
The ability to generate defined null mutations in mice revolutionized the analysis of gene function in mammals. However, gene-deficient mice generated by using 129-derived embryonic stem (ES) cells ma
