Development and heterogeneity of the ILC family

Development and heterogeneity of the innate lymphoid cell (ILC) family. ILCs develop from distinct progenitors in the fetal liver or bone marrow and then develop into mature ILCs in the periphery. Different transcription factors and cytokines are involved in the development of the three groups of mature ILCs. All ILCs develop from CLPs, which can differentiate into NKps or CHILPs. CHILPs can further differentiate into LTi cells through α4β7+ populations or into other ILC populations through differentiation into ILCps. ILC1s express T-bet, are responsive to IL-12, and produce IFN-γ and/or TNF. ILC2s highly express GATA3, are responsive to IL-25, IL-33 and TSLP, and produce IL-4, IL-5, IL-9, IL-13 and amphiregulin. ILC3s express ROR-γt, are responsive to IL-1β and IL-23, and produce IL-17 and/or IL-22. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3893 CPTAC Assay Portal]

本数据集探讨了先天淋巴样细胞（ILC）家族的发育与异质性。ILCs源自胎儿肝脏或骨髓中的不同祖细胞，随后在外周发育为成熟的ILCs。三种成熟的ILCs组别的发育过程中，涉及不同的转录因子和细胞因子。所有ILCs均源自CLPs，这些细胞能够分化为NKps或CHILPs。CHILPs可进一步通过α4β7+细胞群分化为LTi细胞，或通过分化为ILCps进入其他ILC细胞群。ILC1s表达T-bet，对IL-12产生反应，并产生IFN-γ和/或TNF。ILC2s高度表达GATA3，对IL-25、IL-33和TSLP产生反应，并产生IL-4、IL-5、IL-9、IL-13和 amphiregulin。ILC3s表达ROR-γt，对IL-1β和IL-23产生反应，并产生IL-17和/或IL-22。该通路上的蛋白质可通过[https://assays.cancer.gov/available_assays?wp_id=WP3893 CPTAC检测平台]进行靶向检测。