Regioselective Spirostan E‑Ring Opening for the Synthesis of Dihydropyran Steroidal Frameworks
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https://figshare.com/articles/dataset/Regioselective_Spirostan_E_Ring_Opening_for_the_Synthesis_of_Dihydropyran_Steroidal_Frameworks/3123955
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资源简介：
The
regioselective opening of the ring E in spirostan sapogenins
provides new dihydropyran derivatives. This novel side chain is obtained
after a Lewis acid mediated acetolysis followed by an alkaline workup.
The reaction mechanism is analyzed via density functional theory computations,
and both experimental and computational data support the formation
of an oxacarbenium intermediate. The behavior of the title skeletons
under acidic conditions is also investigated.
创建时间：
2016-04-11
