Catalyst Cascade Reactions in ‘One-Flow’ within a Compartmentalized, Green-Solvent ‘Digital Synthesis Machinery’ – End-to-End Green Process Design for Pharmaceuticals.

The ONE-FLOW project translates a ‘vertical hierarchy’ of chemical multistep synthesis with its complex machinery into a self-organising ‘horizontal hierarchy’ of a compartmentalized flow reactor system – a biomimetic digital flow cascade machinery with just one reactor passage. To keep the horizontal hierarchy manageable, orthogonality needs to be increased among the different consecutive reactions.

ONE-FLOW项目将搭载复杂反应装置的多步化学合成垂直层级，转化为分区式流动反应系统的自组织水平层级——该系统为仅含单条反应通道的仿生数字流动级联装置。为维持该水平层级的可管控性，需提升各连续反应间的正交性。