Microglia aging advances through intermediate states that drive inflammatory activation and cognitive decline
收藏NIAID Data Ecosystem2026-05-02 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE211340
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TGFB-signaling is important for the establishment of microglia homeostasis; however, it's role in aging has remained vague. We found that Tgfb1 and TGFB signaling is altered during hippocampal microglia aging. To investigate the effects that microglia-derived Tgfb1 has on microglia aging, we performed scRNA-Seq on Cd11b+ cells from the hippocampus of mature mice where Tgfb1 had been ablated from Cx3cr1 cells post-maturity. scRNA-Seq of Cx3cr1-CreERT Tgfb1 cKO Cd11b+ cells from mature mouse hippocampi
创建时间：
2024-07-04
