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The NuA4 complex promotes Translesion Synthesis (TLS) - mediated DNA damage tolerance

Alliance of Genome Resources2026-08-01 收录

DNA损伤机制

转座合成

数据链接：

https://www.yeastgenome.org/dataset/GSE66176 数据链接链接失效反馈

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资源简介：

DNA lesions can block a replication fork, leading to its collapse and gross chromosomal rearrangements

应用场景：

DNA损伤机制

自由基毒性

Hydrogen selenide is a recurrent metabolite of selenium compounds. However, few experiments studied the direct link between this toxic agent and cell death. To address this question, we first screened

NIAID Data Ecosystem60

Regulation of the RNAPII Pool Is Integral to the DNA Damage Response [TT-seq CSBKO]. Regulation of the RNAPII Pool Is Integral to the DNA Damage Response [TT-seq CSBKO]

DNA损伤机制

转录调控与RNAPII稳定性

In response to transcription-blocking DNA damage, cells orchestrate a multi-pronged reaction, involving transcription-coupled DNA repair, degradation of RNAPII and genome-wide transcription shutdown.

NIAID Data Ecosystem50

Additional file 7 of Characterization of DNA lesions associated with cell-free DNA by targeted deep sequencing

DNA损伤机制

突变体分析

Additional file 7: Table S2. Contribution of mutational signatures.

NIAID Data Ecosystem30

The telomeric DNA damage response occurs in the absence of chromatin decompaction

端粒成像分析

DNA损伤机制

Telomeres are specialized nucleoprotein structures that protect chromosome ends from DNA damage response (DDR) and DNA rearrangements. The telomeric shelterin protein TRF2 suppresses the DDR, and this

NIAID Data Ecosystem60

Structure and Dynamics of Poly(T) Single-Strand DNA: Implications toward CPD Formation

DNA损伤机制

分子动力学模拟

The formation of cyclobutane pyrimidine dimers between adjacent thymines by UV radiation is thought to be the first event in a cascade leading to skin cancer. Recent studies showed that thymine dimers

NIAID Data Ecosystem40

The NuA4 complex promotes Translesion Synthesis (TLS) - mediated DNA damage tolerance

资源简介：

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