shRNA silencing of human fibroblasts for p73 reveals p73 inhibits malignant transformation

ChEBI2008-06-15 更新2026-07-21 收录

肿瘤抑制基因

细胞恶性转化

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shRNA silencing of human fibroblasts for p73 reveals p73 inhibits malignant transformation

创建时间：

2008-06-15

Our study showed that chromosome 1 gene mutations occur frequently in 1p-intact neuroblastoma, but these do not consistently abrogate the function of bonafide tumor suppressors residing on 1p.. Mutational Analysis of 1p Tumor Suppressors in 1p-intact Neuroblastoma

母细胞瘤遗传学

肿瘤抑制基因

Deletion of 1p is associated with poor prognosis in neuroblastoma, however selected 1p-intact patients still experience poor outcomes. Since mutations of 1p genes may produce deleterious functional ef

NIAID Data Ecosystem120

Transcription profiling of transfected A549 lung cancer cell line with new tumor supressor gen ARLTS1 in that shows a very low expression level in comparison with normal lung

肿瘤抑制基因

癌细胞转录组

We have transfected a new tumor suppresor gene named ARLTS1 in A549 lung cancer cell line that shows a very low expression level in comparison with normal lung. This line was transfected using the pMV

NIAID Data Ecosystem50

The effect on gene expression of Smchd1 deletion in premalignant pre-B cells

B细胞淋巴瘤分子机制

肿瘤抑制基因

Smchd1 appears to act as a tumour suppressor in the Eµ-Myc B cell lymphoma model. We find gene expression differences are most pronounced in premalignant cells. We always detect a small number of clus

NIAID Data Ecosystem40

Additional file 2: Table S2. of Concordance of copy number loss and down-regulation of tumor suppressor genes: a pan-cancer study

肿瘤抑制基因

癌细胞研究

The enriched pathways and interactors for the 207 tumor suppress genes (TSGs) with frequent copy number loss (CNL). (XLSX 11 kb)

DataCite Commons2024-12-12 更新60

Cross-validated CE for DiffMut and LOTUS prediction of disease specific TSGs in the single- and multitask settings.

肿瘤抑制基因

多任务学习

Cross-validated CE for DiffMut and LOTUS prediction of disease specific TSGs in the single- and multitask settings.

NIAID Data Ecosystem40