Collaborative Cohort of Cohorts for COVID-19 Research (C4R): Prevent Pulmonary Fibrosis (PrePF)

**<u>Cohort Description</u>**

Prevent Pulmonary Fibrosis (PrePF) has been investigating the clinical, physiologic and genetic phenotypes of interstitial lung disease (ILD) by focusing on families with two or more cases of ILD and individuals with sporadic IPF. It has recruited over 1,200 families with two or more cases of pulmonary fibrosis. These families with pulmonary fibrosis include 2,837 individuals with probable or definite idiopathic interstitial pneumonia (IIP) and 2,404 unaffected FDRs. In addition, PrePF recruited over 10,000 individuals with sporadic idiopathic pulmonary fibrosis (IPF).

**<u>Data Being Submitted</u>**

<li><ul>
Wave 1 questionnaire data includes 397 variables for up to 585 PrePF participants in C4R

**队列描述**

预防肺纤维化研究（Prevent Pulmonary Fibrosis，简称PrePF）旨在通过聚焦于存在2例及以上间质性肺疾病（interstitial lung disease，简称ILD）病例的家族，以及特发性肺纤维化（idiopathic pulmonary fibrosis，简称IPF）散发病例人群，探究间质性肺疾病的临床、生理及遗传表型。该研究已招募超过1200个存在2例及以上肺纤维化病例的家族，此类家族中共包含2837名疑似或确诊特发性间质性肺炎（idiopathic interstitial pneumonia，简称IIP）患者，以及2404名未受影响的一级亲属（first-degree relatives，简称FDR）。此外，PrePF还招募了超过10000名特发性肺纤维化散发病例。

**拟提交数据**

第一波次问卷数据包含397个变量，覆盖C4R队列中最多585名PrePF研究参与者。