Yap/Taz regulates pericyte differentiation in the embryonic kidney
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https://www.ncbi.nlm.nih.gov/sra/SRP331025
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资源简介：
The embryonic renal stroma is highly heterogeneous; however, the significance of this cellular diversity has been poorly understood. Here, we identify a subpopulation of embryonic stroma with enriched Yap/Taz signaling that functions in supporting the developing microvasculature, demonstrating that distinct stromal cells have unique roles in normal renal development. Overall design: Mouse models with deletion of the paralogs Yap and Taz in the stromal lineage were generated by crossing Foxd1cre transgenic with mice carrying loxP-flanked Yap (Yapflox/flox or Yapc/c) or Taz/Wwtr1 (Tazflox/flox or Tazc/c) alleles.
创建时间：
2021-08-09
