MTC interventions through CMEs.

World health organization estimates that of all medicines used globally, about 50% are used irrationally. This is mostly attributed to overuse of antibiotics and indiscriminate use of injectables, among other things. Globally, medicines and therapeutic committees (MTCs) play a significant role in combating inappropriate medicines use problems. This study explored the extent of the functionality of MTCs in health facilities in Uganda and the associated factors. This was a longitudinal assessment that utilised a semistructured questionnaire that was administered through face-to-face interviews. Panel data analysis techniques were used to compare results between the two waves. This study utilised the ordered logistic regression model and random effects techniques to determine the factors influencing the functionality of MTCs. Overall, the percentage of health facilities with a functional MTC significantly increased from 8.3% (22/264) in wave one to 20.8% (55/265) in wave two (p-value = 0.000). The percentage of MTCs that are partially functioning increased from 15.2% (40/264) in wave one to 29.1% (77/265) in wave two. The percentage of HFs with MTC structures increased from 2.6% to 42.6% in wave two. Health facilities without an MTC significantly reduced from 72% (190/264) in wave one to 7.6% (20/265) in wave two (p-value = 0.0000). The median number of MTC members significantly increased from 13 in wave one to 15 members in wave two (p-value = 0.0112). Level of care, availability of guidelines, availability of subcommittees, and MTC members being active were significantly associated with the performance of MTCs (p-value据世界卫生组织（World Health Organization）估算，全球使用的药物中约有50%存在不合理使用的情况。该现象主要归因于抗生素过度使用、注射剂无差别滥用等多种因素。全球范围内，药物与治疗委员会（Medicines and Therapeutic Committees, MTCs）在应对不合理用药问题上发挥着重要作用。本研究针对乌干达各卫生机构内药物与治疗委员会的功能发挥程度及其相关影响因素展开了探索。本研究采用纵向评估方案，通过面对面访谈的方式发放半结构化问卷进行数据收集，并运用面板数据分析技术对两轮调研的结果进行对比分析。本研究同时运用有序logistic回归模型（ordered logistic regression model）与随机效应（random effects）分析方法，以明确影响药物与治疗委员会功能发挥的相关因素。总体而言，设有功能完善的药物与治疗委员会的卫生机构占比从第一轮调研的8.3%（22/264）显著提升至第二轮调研的20.8%（55/265）（p值=0.000）。功能部分发挥的药物与治疗委员会占比从第一轮调研的15.2%（40/264）提升至第二轮调研的29.1%（77/265）。设有药物与治疗委员会架构的卫生机构占比在第二轮调研中从2.6%提升至42.6%。未设立药物与治疗委员会的卫生机构占比从第一轮调研的72%（190/264）大幅降至第二轮调研的7.6%（20/265）（p值=0.0000）。药物与治疗委员会成员的中位数数量从第一轮调研的13人显著提升至第二轮调研的15人（p值=0.0112）。照护层级、指南可及性、小组委员会的设立情况以及药物与治疗委员会成员的活跃度，均与药物与治疗委员会的运行绩效存在显著关联（p值