OPTIMIZATION OF SYNTHESIS OF INTERCALATED NANOCOMPOSITE HIDROGELS FOR FUTURE APPLICATION IN THE MEDICAL AREA

In this study, the hydrogel formulations based on polysaccharide sodium alginate were investigated for further development of intercalated nanocomposite hydrogels, for purposes of future applications in the areas of health as a carrier in drug delivery systems. Thus, the objective of the work dealt with in the optimization of hydrogels synthesis and obtaining nanostructured hydrogels with clay in an intercalated conformation. The optimization of the hydrogel synthesis was successful, and it is possible to define the materials and / or solutions to be used and concentrations of these solutions to the best formulations of hydrogels. The choice of the concentration of the polysaccharide, the type of crosslinking agent and nanofiller to continued development work, it was determined following criteria as the degree of swelling, and in some cases the physical properties, contributed to determine the best hydrogels. The development of intercalated nanocomposites hydrogel beads was confirmed by the X-ray diffraction technique, which thus could be used to observe evidence of effective incorporation or intercalation of the nanoclay in the hydrogel matrix.

本研究以多糖海藻酸钠为基底制备水凝胶配方，旨在开发插层型纳米复合水凝胶，以期未来作为药物递送系统载体应用于健康医疗领域。据此，本研究的核心目标为优化水凝胶合成工艺，并制备出具有黏土插层结构的纳米结构化水凝胶。目前水凝胶合成优化工作已取得成功，可明确制备最优水凝胶配方所需的原料、溶剂及各溶液浓度。研究通过溶胀度指标，结合部分物理性能参数，确定了多糖浓度、交联剂类型及纳米填料的筛选标准，以此筛选出最优水凝胶配方，为后续开发工作提供依据。经X射线衍射技术表征，已证实插层型纳米复合水凝胶微球的成功制备，该结果可直观证明纳米黏土已有效掺入水凝胶基体并形成插层结构。