C−H Activations at Iridium(I) Square-Planar Complexes Promoted by a Fifth Ligand

In the presence of ligands such as acetonitrile, ethylene, or propylene, the Ir(I) complex [Ir(1,2,5,6-η-C8H12)(NCMe)(PMe3)]BF4 (1) transforms into the Ir(III) derivatives [Ir(1-κ-4,5,6-η-C8H12)(NCMe)(L)(PMe3)]BF4 (L = NCMe, 2; η2-C2H4, 3; η2-C3H6, 4), respectively, through a sequence of C−H oxidative addition
and insertion elementary steps. The rate of this transformation depends on the nature of L and, in the case
of NCMe, the pseudo-first-order rate constants display a dependence upon ligand concentration suggesting
the formation of five-coordinate reaction intermediates. A similar reaction between 1 and vinyl acetate affords
the Ir(III) complex [Ir(1-κ-4,5,6-η-C8H12){κ-O-η2-OC(Me)OC2H3}(PMe3)]BF4 (7) via the isolable five-coordinate
Ir(I) compound [Ir(1,2,5,6-η-C8H12){κ-O-η2-OC(Me)OC2H3}(PMe3)]BF4 (6). DFT (B3LYP) calculations in model
complexes show that reactions initiated by acetonitrile or ethylene five-coordinate adducts involve C−H
oxidative addition transition states of lower energy than that found in the absence of these ligands. Key
species in these ligand-assisted transformations are the distorted (nonsquare-planar) intermediates
preceding the intramolecular C−H oxidative addition step, which are generated after release of one
cyclooctadiene double bond from the five-coordinate species. The feasibility of this mechanism is also
investigated for complexes [IrCl(L)(PiPr3)2] (L = η2-C2H4, 27; η2-C3H6, 28). In the presence of NCMe, these
complexes afford the C−H activation products [IrClH(CHCHR)(NCMe)(PiPr3)2] (R = H, 29; Me, 30) via
the common cyclometalated intermediate [IrClH{κ-P,C-P(iPr)2CH(CH3)CH2}(NCMe)(PiPr3)] (31). The most
effective C−H oxidative addition mechanism seems to involve three-coordinate intermediates generated
by photochemical release of the alkene ligand. However, in the absence of light, the reaction rates display
dependences upon NCMe concentration again indicating the intermediacy of five-coordinate acetonitrile
adducts.