MiRNA and Target Gene Data of Preconditioned Extracellular Vesicles Derived from Umbilical Cord Mesenchymal Stem Cells Treatment In Biliary Atresia Rat Liver

Biliary atresia (BA) is a severe liver disease affecting infants, leading to fibrosis and cirrhosis if untreated. The innovative therapeutic approach using preconditioned extracellular vesicles (EVs) derived from umbilical cord mesenchymal stem cells (UC-MSCs) has shown promise in mitigating liver damage and promoting liver regeneration. The preconditioning of UC-MSCs enhances the therapeutic potential of EVs by enriching them with bioactive molecules, particularly microRNAs (miRNAs).
This study aims to characterize the miRNA and target gene profiles of preconditioned EVs derived from UC-MSCs and evaluate their therapeutic effects on BA in a rat model. By understanding the miRNA content and their target genes, we can elucidate the molecular mechanisms through which these EVs exert their hepatoprotective effects.
Preconditioned EVs derived from UC-MSCs represent a potent therapeutic strategy for BA. The miRNA and target gene data provide valuable insights into the molecular mechanisms underlying the therapeutic effects, paving the way for further clinical translation and development of EV-based therapies for liver diseases.