Archived data_WestCM.xlsx

Comparison between high-altitude versus low-altitude populations of deer mice, before and after chronic exposure to hypoxia in adulthood. SPECT-CT scanning was used to measure lung volume and various indices of ventilation-perfusion matching (log SDV, log SDQ, RDV, RDQ, Mean Log(V/Q), SD Log(V/Q), shunt perfusion, and dead space ventilation). Right ventricle systolic pressure (RVSP), right ventricle (RV) mass relative to left ventricle plus septum (LV+S), and smooth muscle (SM) thickness in pulmonary arterial vessels were also measured to evaluate hypoxic pulmonary hypertension. Additional details can be found in the associated publication: West et al. Pulmonary hypertension is attenuated and ventilation-perfusion matching is maintained during chronic hypoxia in deer mice native to high altitude.<br>本数据集针对高海拔与低海拔鹿鼠种群，分析其在成年期接受慢性低氧暴露前后的表型差异。研究采用SPECT-CT扫描技术，测定了肺容积以及通气-血流灌注匹配（ventilation-perfusion matching）的多项指标，包括log SDV、log SDQ、RDV、RDQ、平均Log(V/Q)、SD Log(V/Q)、分流灌注量与死腔通气量。此外还测定了右心室收缩压（RVSP）、右心室（RV）质量与左心室加室间隔（LV+S）的质量比值，以及肺动脉血管平滑肌（SM）厚度，以此评估低氧性肺动脉高压。更多详细信息可参阅相关研究文献：West 等发表的《高海拔原生鹿鼠在慢性低氧期间肺动脉高压得以缓解且通气-血流灌注匹配得以维持》。