Effect of GDNF-Gel/HA-Mg nerve conduit on gene expression during peripheral nerve regeneration

In this study, glial cell line-derived neurotrophic factor (GDNF)- Gelatin methacryloyl (Gel)/hydroxylapatite (HA)-Mg nerve conduit was developed. the conduit was implanted in sciatic nerve defect model in SD rats to explore its role in repairing peripheral nerve defects. Regenerated nerve tissues from GDNF-Gel/HA-Mg group and negative control group were collected for RNA-seq, aiming to explore the potential molecular mechanism of GDNF-Gel/HA-Mg in peripheral nerve regeneration. To investigate the potential molecular mechanism of GDNF-Gel/HA-Mg in peripheral nerve regeneration, GDNF-Gel/HA-Mg was implanted in SD rats, the regenerated nerves were collected for RNA-seq.The control group (NC group) received no treatment and the wounds were closed directly, the regenerated nerves from NG group were used as controls.