Comparison of gamma and x-ray irradiation for myeloablation and establishment of normal and autoimmune syngeneic bone marrow chimeras

Here, we present our assessment of the hematopoietic and immunological niches in two different bone marrow chimera models: a simple complete, syngeneic model and a more complex, syngeneic and mixed bone marrow model of autoimmunity. The latter model is of particular relevance, due to the potential differential impact of the radiation types on superficial tissues and baseline inflammatory status of the animals.
Conclusion:
In conclusion, we found that the biological effects of Cs-137 and X-ray irradiators are comparable with regards to reconstitution chimerism in normal and autoimmune settings. Indeed, as of October 2019, our institution has migrated completely to non-radionuclide irradiation technology. Taken together, the results presented here provide a compelling argument for a continued global transition to safer alternatives to radioactive sources.