Ni-Catalyzed Enantioselective Reductive Diarylation of Activated Alkenes by Domino Cyclization/Cross-Coupling

A Ni-catalyzed enantioselective
reductive diarylation of activated
alkenes by domino cyclizative/cross-coupling of two aryl bromides
is developed. This reaction proceeds under very mild conditions and
shows broad substrate scope, without requiring the use of preformed
organometallic reagents. Moreover, this approach provides direct access
to various bis-heterocycles bearing all-carbon quaternary centers
in synthetically useful yields (up to 81%) with excellent enantioselectivity
(>30 examples, 90–99% ee).