Motor challenge constrains multiscale cardiac autonomic organization in Parkinson's disease: RR-interval dataset and analysis pipeline

This Zenodo deposit provides the de-identified RR-interval dataset (Polar H10) and the full Python analysis pipeline used to generate the tables/figures and statistical results reported in the manuscript “Motor Challenge Constrains Multiscale Cardiac Autonomic Organization in Parkinson’s Disease”. Participants (young adults, older adults, and patients with Parkinson’s disease) completed three epochs: seated rest (10 min), unobstructed walking (4 min), and obstacle negotiation (4 min). The pipeline computes time-domain HRV (MeanRR, MeanHR, SDNN, RMSSD), entropy metrics (ApEn; multiscale entropy at selected scales), derives a PCA-based Complexity Index (CI), and runs generalized estimating equations (GEE) models with mean heart rate adjustment. A PD-only sensitivity analysis optionally incorporates levodopa equivalent daily dose (LEDD) when pd_ledd.csv is provided. All outputs are written to outputs/tables and outputs/figures.本Zenodo存档提供了去标识化的RR间期数据集（搭载Polar H10设备采集），以及用于复现论文《运动挑战约束帕金森病患者的多尺度心脏自主神经调控组织》（Motor Challenge Constrains Multiscale Cardiac Autonomic Organization in Parkinson’s Disease）中报告的表格、图表与统计结果的完整Python分析流程。研究对象涵盖青年成年人、老年成年人与帕金森病患者，所有受试者均完成三个实验阶段：静息坐姿状态（10分钟）、无障碍行走（4分钟）以及障碍物穿行任务（4分钟）。该分析流程可计算时域心率变异性（Heart Rate Variability, HRV）指标，包括平均RR间期（MeanRR）、平均心率（MeanHR）、正常窦性RR间期标准差（SDNN）、相邻正常RR间期差值均方根（RMSSD）；熵值类指标，涵盖近似熵（ApEn）以及选定尺度下的多尺度熵；还可导出基于主成分分析（Principal Component Analysis, PCA）的复杂度指数（Complexity Index, CI），并构建校正平均心率的广义估计方程（Generalized Estimating Equations, GEE）模型。当提供pd_ledd.csv文件时，仅针对帕金森病患者的敏感性分析可可选纳入左旋多巴等效日剂量（Levodopa Equivalent Daily Dose, LEDD）参数。所有分析结果均将输出至outputs/tables与outputs/figures目录下。