Crystal structure of the human METTL3-METTL14 in complex with small molecule inhibitor Compound 56

Crystal structure of the human METTL3-METTL14 in complex with small molecule inhibitor Compound 56 Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 4-[(3~{R})-3-(cyclopropylmethylamino)piperidin-1-yl]-1-[(1~{R})-1-[4-[5-(dimethylamino)pyridin-3-yl]-1,2,3-triazol-1-yl]ethyl]pyridin-2-one, CALCIUM ION, ... Authors: Dutheuil, G, Oukoloff, K. Deposit date: 2024-07-16 Release date: 2025-02-12 Last modified: 2025-08-27 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Discovery, Optimization, and Preclinical Pharmacology of EP652, a METTL3 Inhibitor with Efficacy in Liquid and Solid Tumor Models. J.Med.Chem., 68, 2025人类METTL3-METTL14与小分子抑制剂Compound 56结合的晶体结构 配体描述：2-氨基-2-羟甲基-丙烷-1,3-二醇、4-[(3R)-3-(环丙基甲氨基)哌啶-1-基]-1-[(1R)-1-[4-[5-(二甲氨基)吡啶-3-基]-1,2,3-三唑-1-基]乙基]吡啶-2-酮、钙离子等 作者：迪特勒伊（Dutheuil, G）、乌科洛夫（Oukoloff, K） 提交日期：2024-07-16 发布日期：2025-02-12 最后修改日期：2025-08-27 实验方法：X射线衍射（分辨率1.95 Å） 引用文献：《EP652的发现、优化与临床前药理学研究——一种在液体及实体瘤模型中具有药效的METTL3抑制剂》，《药物化学杂志（J.Med.Chem.）》，2025年，第68卷