Crystal structure of fragment 3-(3-Methyl-4-oxo-3,4-dihydroquinazolin-2-yl)propanoic acid bound in the ubiquitin binding pocket of the HDAC6 zinc-finger domain

Crystal structure of fragment 3-(3-Methyl-4-oxo-3,4-dihydroquinazolin-2-yl)propanoic acid bound in the ubiquitin binding pocket of the HDAC6 zinc-finger domain Descriptor: 3-(3-methyl-4-oxo-3,4-dihydroquinazolin-2-yl)propanoic acid, Histone deacetylase 6, UNKNOWN ATOM OR ION, ... Authors: Harding, R.J, Halabelian, L, Ferreira de Freitas, R, Franzoni, I, Ravichandran, M, Lautens, M, Santhakumar, V, Schapira, M, Bountra, C, Edwards, A.M, Arrowsmith, C.M, Structural Genomics Consortium (SGC) Deposit date: 2018-02-11 Release date: 2018-02-28 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Identification and Structure-Activity Relationship of HDAC6 Zinc-Finger Ubiquitin Binding Domain Inhibitors. J. Med. Chem., 61, 2018

结合于组蛋白去乙酰化酶6（Histone deacetylase 6, HDAC6）锌指结构域泛素结合口袋的3-(3-甲基-4-氧代-3,4-二氢喹唑啉-2-基)丙酸片段的晶体结构。描述信息：3-(3-甲基-4-氧代-3,4-二氢喹唑啉-2-基)丙酸、组蛋白去乙酰化酶6（Histone deacetylase 6, HDAC6）、未知原子或离子……。作者：Harding, R.J.、Halabelian, L.、Ferreira de Freitas, R.、Franzoni, I.、Ravichandran, M.、Lautens, M.、Santhakumar, V.、Schapira, M.、Bountra, C.、Edwards, A.M.、Arrowsmith, C.M.，结构基因组学联盟（Structural Genomics Consortium, SGC）。提交日期：2018-02-11，发布日期：2018-02-28，最后修改日期：2023-10-04。实验方法：X射线衍射（分辨率1.7埃）。引用文献：《HDAC6锌指泛素结合域抑制剂的鉴定与构效关系》，《药物化学杂志》（J. Med. Chem.），第61卷，2018年