Synthesis of a New Class of β-Iodo N-Alkenyl 2-Pyridones

A new method for the synthesis of β-iodo N-alkenyl 2-pyridones from substituted 2-propargyloxypyridines has been discovered . These compounds present a unique complement of orthogonal functionality and structural characteristics that are unavailable via other routes. The ready access to these compounds renders them an important entry point for the preparation of more complex N-alkyl pyridone-containing targets.本研究开发出一种以取代2-炔丙氧基吡啶（substituted 2-propargyloxypyridines）为起始原料，合成β-碘代N-烯基-2-吡啶酮（β-iodo N-alkenyl 2-pyridones）的全新方法。该类化合物所兼具的正交官能团（orthogonal functionality）与结构特性组合独具一格，且无法通过其他合成路径获取。鉴于此类化合物可便捷获得，它们成为制备更复杂含N-烷基吡啶酮（N-alkyl pyridone）结构目标分子的重要合成切入点。