Structure-activity relationship: charged ethyltrimethylamine critical for target potency.

aIC50 (µM), mean±SEM, n = 3-14 independent experiments per assay per compound.Structure-activity relationship: charged ethyltrimethylamine critical for target potency.aIC50（单位：µM）以平均值±标准误（mean±SEM）表示，每种化合物的每项检测对应3至14次独立实验。构效关系（Structure-Activity Relationship）研究表明，带电荷的三甲基乙胺基团对靶点活性至关重要。