Cell type distribution in female and male mouse brains / Npy1_GFP_M9_201014

This project proposes to establish an Anatomical Collaboratory for Systematic Atlasing of Cell-Type Distribution and Morphology in female and male brain. This Collaboratory will apply standardized, unbiased and largely automated methods developed in the group’s laboratories to atlas the distribution and morphology of >80 molecularly defined cell classes and cell type across all regions of the female and male brain. This work will yield the most comprehensive characterization of cell type anatomy in the mammalian brain to date, establishing a structural basis for building an integrated Cell Type Brain Atlas.

本项目拟建立解剖学协作研究平台（Anatomical Collaboratory），用于系统性绘制雌雄大脑的细胞类型分布与形态学图谱。该平台将运用本团队实验室开发的标准化、无偏倚且高度自动化的研究方法，对覆盖雌雄大脑全脑区的80余种经分子定义的细胞类群与细胞类型的分布及形态开展图谱绘制工作。本研究将产出迄今最全面的哺乳动物大脑细胞类型解剖学特征表征，为构建整合式细胞类型脑图谱（Cell Type Brain Atlas）奠定结构基础。