GABAergic synapse

Gamma aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter in the mammalian central nervous system (CNS). GABA binds to ionotropic GABA(a) receptors that mediate fast GABA responses by triggering chloride channel openings and metabotropic GABA(b) receptor that trigger slower responses by activating G-proteins and influencing second messenger systems. Glycine exerts its inhibitory effects via specific glycine receptors (GlyRs) anion channel and the resulting influx of Cl− ions hyperpolarizes the postsynaptic cell, thereby inhibiting neuronal firing.