Differentially expressed genes in synovial tissue on days 3 and 14.

Synovial tissue was harvested at baseline, 3- and 14-days post-injury/bleed with treatment by Saline (vehicle), rhFVIII, or mFcFVIII. Limma DGE analysis was performed (see Methods) between injured-saline vs baseline (day 3 or 14) samples, between injured-saline vs injured-rhFVIII, and injured-saline vs injured-mFcFVIII samples. The significant genes, with adjusted p-value (XLSX)实验于基线期、损伤/出血后3天及14天采集滑膜组织，受试对象分别接受生理盐水（赋形剂）、重组人凝血因子VIII（rhFVIII）或嵌合Fc融合凝血因子VIII（mFcFVIII）处理。采用Limma差异基因表达（DGE）分析方法（详见方法部分）对以下三组样本开展比较分析：损伤后生理盐水处理组样本与基线期（第3天或第14天）样本、损伤后生理盐水处理组样本与损伤后rhFVIII处理组样本，以及损伤后生理盐水处理组样本与损伤后mFcFVIII处理组样本。本数据集包含校正后P值显著的差异基因相关数据，数据以XLSX格式存储。