White Matter Injury Due to Experimental Chronic Cerebral Hypoperfusion Is Associated with C5 Deposition

The C5 complement protein is a potent inflammatory mediator that has been implicated in the pathogenesis of both stroke and neurodegenerative disease. Microvascular failure is proposed as a potential mechanism of injury. Along these lines, this investigation examines the role of C5 in the setting of chronic cerebral hypoperfusion. Following experimental bilateral carotid artery stenosis, C5 protein deposition increases in the corpus callosum over thirty days (p补体C5蛋白（C5 complement protein）是一种强效炎症介质，已被证实与脑卒中及神经退行性疾病的发病机制密切相关。研究提出微血管衰竭是该类损伤的潜在致病机制。据此，本研究探讨了补体C5在慢性脑低灌注状态下的作用。在构建实验性双侧颈动脉狭窄模型后，胼胝体中的补体C5蛋白沉积在30天内显著升高（p