Expression data from IGRA positive and IGRA negative

Treatment of latent tuberculosis infection (LTBI) in individuals at greatest risk for reactivation is an important component of TB control and elimination strategies. However, blood biomarkers for monitoring LTBI treatment have not been identified. We performed a microarray analysis to identify the gene expression profile in whole blood from healthy individuals reactive to the tuberculin skin test (TST) with/without a positive in-house interferon-γ release assay (IGRA) before and after isoniazid (INH) prophylactic therapy. Volunteers who were in contact with TB cases and TST positive were recruited. Samples were classified into two main groups according to IGRA status: IGRA-positive and IGRA-negative. Three time measurements control (t0) plus isoniazid treatment after 1 month (t1) and after 6 months (t6) created six groups for differential expression analysis.