Additional file 16 of Comparison between 5 extractions methods in either plasma or serum to determine the optimal extraction and matrix combination for human metabolomics

Additional file 16. Table S12. Summary of matrix observed effects observed for labeled standard analytes across all extraction methods and LC-MS analyses. Not all analytes were successfully detected in plasma or serum. Matrix effect in the range of 0.80 < ME < 1.20 are considered as negligible and labelled as “no matrix effect”. ME values below 0.80 were considered as ion suppression, and those above 1.20 as ion enhancement. Empty boxes stands not detected. MeOH : methanol; MeOH:ACN : methanol combined with acetonitrile; ACN: acetonitrile; SPE : solid preparation extraction; ESI : electrospray ionisation; RP: reverse phase.

补充材料16：表S12。标记标准分析物在所有萃取方法及液相色谱-质谱（LC-MS）分析中的基质效应实测汇总。并非所有分析物均可在血浆或血清中被成功检出。基质效应（matrix effect）取值介于0.80 < ME < 1.20时，可视为可忽略，标注为"无基质效应"。ME值低于0.80时判定为离子抑制，高于1.20时则判定为离子增强。空框代表未检出。MeOH：甲醇（methanol）；MeOH:ACN：甲醇与乙腈的混合体系；ACN：乙腈（acetonitrile）；SPE：固相制备萃取（solid preparation extraction）；ESI：电喷雾电离（electrospray ionisation）；RP：反相。