Pre-conception status, obstetric outcome and use of medications during pregnancy of systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) in Japan: Multi-center retrospective descriptive study

<b>Objective:</b> To describe the pre-conception status, pregnancy outcomes, and medication prevalence in systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Crohn’s disease (CD), and ulcerative colitis (UC). <b>Methods:</b> E-mail-based questionnaire survey for the Japan Maternal Fetal Intensive Care Unit Network hospitals inquiring prevalence and clinical features of SLE, RA, CD and UC complicated pregnancies for 2 years. <b>Results:</b> The number of SLE, RA, CD and UC among 69,810 deliveries was 184, 139, 27 and 178, respectively. Less than half of pregnancies were planned. Assisted reproductive technology (ART) pregnancy rates were higher in SLE, RA and UC than in the general population (11.4, 23.0 and 7.4 vs 5.1%, <i>p</i> p p p p p p <b>Conclusion:</b> SLE, RA, CD, and UC complicated pregnancies were at high risks of obstetric adverse outcome. High ART rates necessitate pre-conception counseling in SLE, RA, and UC pregnancies.

【研究目的】：阐明系统性红斑狼疮（systemic lupus erythematosus, SLE）、类风湿关节炎（rheumatoid arthritis, RA）、克罗恩病（Crohn’s disease, CD）及溃疡性结肠炎（ulcerative colitis, UC）患者的孕前状态、妊娠结局与用药率情况。
【研究方法】：采用基于电子邮件的问卷调查方式，针对日本母婴重症监护网络医院开展为期2年的调研，收集合并上述四种疾病的妊娠病例的患病率及临床特征数据。
【研究结果】：在69810例分娩病例中，合并SLE、RA、CD及UC的病例数依次为184例、139例、27例与178例。仅不足半数的妊娠为计划性妊娠。SLE、RA及UC患者的辅助生殖技术（assisted reproductive technology, ART）妊娠率均高于普通人群（分别为11.4%、23.0%、7.4%，相较于普通人群的5.1%，*p*<i>p</i><i>p</i><i>p</i><i>p</i><i>p</i>）。
【研究结论】：合并SLE、RA、CD及UC的妊娠发生产科不良结局的风险较高。SLE、RA及UC患者较高的ART妊娠率提示，需针对此类人群开展孕前咨询服务。