Transcriptome-wide occupancies of IFIT1 and eIF3C in osteogenic PDLSCs treated with GLP1R knockdown

We have observed that the expression of IFIT1, IFIT2, IFIT3 and the other genes related interferon are all elevated by GLP1R knockdown whereas reduced by GLP1RA and 2GRA in multiple lineages differentiation systems of PDLSCs. It was reported that IFIT proteins could block the formation of 43S pre-initiation complex and 48S initial complex via interacting with eIF3E and eIF3C. RIP-seq was conducted to study the transcriptome-wide occupancies of IFIT1 and eIF3C in osteogenic PDLSCs treated with GLP1R knockdown compared to regular osteogenesis.