TARGET: Neuroblastoma (NBL)

There are ~214 fully characterized patient cases with neuroblastoma (all tumor/normal pairs, 10 with relapse sample as well) that will make up the TARGET NBL dataset, along with some cell lines and xenografts. The dataset includes 24 4S cases as well. Each fully characterized case has gene expression, tumor and paired normal copy number analyses, methylation and comprehensive next-generation sequencing to include whole genome and/or whole exome sequencing. A majority of these cases will also have mRNA-seq and methylation data available as well. There are additionally a large number of cases, both low and high risk, with partial molecular characterization to include some next generation and targeted Sanger sequencing making this a large and informative genomic dataset. All cases can be sorted according to data type via the Case Matrix on the TARGET Data Matrix. Please visit the TARGET website listed above for additional information on this and other TARGET... (for more see dbGaP study page.)

本TARGET NBL数据集包含约214例完成全面分子特征注释的神经母细胞瘤患者病例（均为肿瘤-正常组织配对样本，其中10例同时带有复发样本），同时纳入部分细胞系与异种移植模型。该数据集还包含24例4S型神经母细胞瘤病例。每一例完成全面特征注释的病例均配有基因表达谱、肿瘤及配对正常组织的拷贝数分析数据、甲基化组学数据，以及包含全基因组测序和/或全外显子组测序在内的全面下一代测序数据。其中大部分病例还额外提供mRNA测序（mRNA-seq）与甲基化组学数据。此外，数据集还涵盖大量低危与高危神经母细胞瘤病例，仅完成部分分子特征注释，包含部分下一代测序与靶向桑格测序数据，整体构成一个规模庞大且信息丰富的基因组学数据集。所有病例均可通过TARGET数据矩阵（TARGET Data Matrix）中的病例矩阵按数据类型进行筛选分类。如需获取本数据集及其他TARGET项目的更多信息，请访问上述TARGET官方网站（详细信息可查阅dbGaP研究页面）。

搜集汇总

背景与挑战

背景概述

该数据集聚焦于神经母细胞瘤研究，包含214个完全表征的患者病例及额外部分特征病例，涵盖基因表达、拷贝数分析、甲基化和下一代测序等多维度数据。数据集由NIH组织，具有重要的医学研究价值。