Electrochemotherapy treatment of oral extramedullary plasmacytoma of the tongue: a retrospective study of three dogs

ABSTRACT: Extramedullary plasmacytomas (EPs) are responsible for 2.5% of neoplasms in dogs. They are solitary, smooth, elevated, pink or red nodules, of 1 to 2cm in diameter. Cutaneous and oral extramedullary plasmacytomas in dogs are usually benign tumors, treated with local therapies. Prognosis is generally good. Recurrence and metastatic rates are low. Electrochemotherapy is a local treatment that combines chemotherapy and electroporation and shows objective responses of 70% to 94% with few local and systemic side effects. This scientific communication has the objective to report treatment of three canine patients with oral extramedullary plasmacytoma. Nodules were located on the tongue and patients were submitted to one or two electrochemotherapy sessions, which preserved the tongue without mutilation and cured the patients.

摘要：髓外浆细胞瘤（Extramedullary plasmacytomas，EPs）约占犬类肿瘤的2.5%。该类肿瘤表现为单发、质地平滑、隆起性的粉色或红色结节，直径为1~2厘米。犬类皮肤及口腔髓外浆细胞瘤多为良性肿瘤，可通过局部疗法进行治疗，整体预后良好，复发率与转移率均较低。电化学疗法（electrochemotherapy）是一种联合化疗与电穿孔（electroporation）的局部治疗手段，客观缓解率可达70%~94%，且局部与全身性不良反应均较为轻微。本科研通讯旨在报道3例口腔髓外浆细胞瘤患犬的治疗案例：肿瘤结节均位于舌部，患犬接受1至2次电化学疗法治疗后，成功保留舌部未造成毁损并实现治愈。