Multivariable Cox Proportional Hazard Models for Time to first AIDS-defining event or severe non AIDS-defining event or death.

List of abbreviations: AIDS, acquired immunodeficiency syndrome; CI, confidence interval; HAART, highly-active antiretroviral treatment; HBsAg, hepatitis B surface antigen; HCV-Ab, hepatitis C virus antibodies; HIV, human immunodeficiency virus; INR, immunological non-responders; IR, Immunological responders; NNRTI, non-nucleoside reverse transcriptase inhibitor; PI, protease inhibitor.1 The first model was adjusted for age and gender.2 The second model was adjusted for age, gender, intravenous drug use as route of HIV transmission, pre-HAART CD4+ T-cell count, occurrence of AIDS-defining events and immunological response (Immunological non responders at year 1 versus responders). Occurrence of AIDS-defining event during follow-up was considered as time-dependent variable* Estimates for HCV-Ab positivity were not adjusted for intravenous drug use as route of HIV transmission, due to high correlation.Multivariable Cox Proportional Hazard Models for Time to first AIDS-defining event or severe non AIDS-defining event or death.缩略语列表：获得性免疫缺陷综合征（AIDS, acquired immunodeficiency syndrome）；置信区间（CI, confidence interval）；高效抗反转录病毒治疗（HAART, highly-active antiretroviral treatment）；乙型肝炎表面抗原（HBsAg, hepatitis B surface antigen）；丙型肝炎病毒抗体（HCV-Ab, hepatitis C virus antibodies）；人类免疫缺陷病毒（HIV, human immunodeficiency virus）；免疫学无应答者（INR, immunological non-responders）；免疫学应答者（IR, Immunological responders）；非核苷类反转录酶抑制剂（NNRTI, non-nucleoside reverse transcriptase inhibitor）；蛋白酶抑制剂（PI, protease inhibitor）。1 首个模型针对年龄与性别进行了校正。2 第二个模型校正因素包括年龄、性别、以静脉吸毒作为人类免疫缺陷病毒传播途径、高效抗反转录病毒治疗前CD4+ T细胞计数、艾滋病定义性事件的发生情况以及免疫学应答状态（第1年免疫学无应答者与应答者对比）。随访期间艾滋病定义性事件的发生被视为时依变量*。鉴于静脉吸毒作为人类免疫缺陷病毒传播途径与其他因素存在高度相关性，丙型肝炎病毒抗体（HCV-Ab）阳性的相关估计值未针对该传播途径进行校正。本研究采用多变量Cox比例风险模型，分析首次发生艾滋病定义性事件、严重非艾滋病定义性事件或死亡的时间。