Chay1997_CalciumConcentration

This a model from the article:

Effects of extracellular calcium on electrical bursting and intracellular and luminal calcium oscillations in insulin secreting pancreatic beta-cells.

Chay TR
Biophys J.1997 Sep;73(3):1673-88.
9284334,

Abstract:

The extracellular calcium concentration has interesting effects on bursting of pancreatic beta-cells. The mechanism underlying the extracellular Ca2+ effect is not well understood. By incorporating a low-threshold transient inward current to the store-operated bursting model of Chay, this paper elucidates the role of the extracellular Ca2+ concentration in influencing electrical activity, intracellular Ca2+ concentration, and the luminal Ca2+ concentration in the intracellular Ca2+ store. The possibility that this inward current is a carbachol-sensitive and TTX-insensitive Na+ current discovered by others is discussed. In addition, this paper explains how these three variables respond when various pharmacological agents are applied to the store-operated model.

This model was taken from the
CellML repository and automatically converted to SBML.

The original model was:

Chay TR (1997) - version05

The original CellML model was created by:

Lloyd, Catherine, May

[e-mail]

The University of Auckland

The Bioengineering Institute

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