Degradation of Cyclin K/CDK12 is a druggable vulnerability of colorectal cancer (H012)
收藏NIAID Data Ecosystem2026-03-11 收录
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https://www.omicsdi.org/dataset/ega/EGAS00001004517
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Here, we screened a library of non-characterized small molecules against CRC patient-derived tumor spheroid culture (TSC) cells to identify a compound (NCT02) with activity in a subset of TSCs. Transcriptomics as well as thermal proteome profiling and chemical proteomics identified degradation of cyclin K (CCNK) and CDK12 as central mechanism-of-action, associated with increase of DNA damage and induction of apoptosis.EGA study EGAS00001004517
创建时间：
2020-08-10
