Supplementary Material for: Meta-Analysis Shows Strong Positive Association of the TNF-α Gene with Tumor Stage in Bladder Cancer

There is no consensus on the association between the tumor necrosis factor-α (TNF-α) gene promoter –308 A/G single nucleotide polymorphisms and bladder cancer risk. To obtain a more precise estimation of this correlation, we conducted a meta-analysis. The PubMed, MEDLINE, Cochrane Library and China National Knowledge Infrastructure (CNKI) databases were searched for relevant published studies. Seven case-control studies with a total of 1,311 cases and 1,436 controls were identified and analyzed. A notable correlation was observed between the TNF-α genotype and bladder cancer grade (AA+GA vs. GG; odds ratio 1.96, 95% confidence interval 1.37–2.80, p = 0.0002). In summary, this meta-analysis demonstrates that the TNF-α –308 AA+GA genotype may be a marker to the tumor-invasive stage of bladder cancer.目前针对肿瘤坏死因子-α（tumor necrosis factor-α, TNF-α）基因启动子–308 A/G单核苷酸多态性与膀胱癌风险的关联尚未达成统一共识。为更精准地评估该关联，本研究开展了一项荟萃分析。本研究检索了PubMed、MEDLINE、Cochrane图书馆及中国知网（China National Knowledge Infrastructure, CNKI）数据库中的相关已发表文献。最终纳入7项病例对照研究，共计1311例病例与1436例对照，并对其进行了分析。研究观察到TNF-α基因型与膀胱癌分级间存在显著关联（AA+GA基因型与GG基因型相比：比值比为1.96，95%置信区间为1.37–2.80，p=0.0002）。综上，本项荟萃分析表明，TNF-α–308位点AA+GA基因型或可作为膀胱癌侵袭性肿瘤分期的标志物。