The top 10 potential drugs identified for Alzheimer’s disease.

Figshare2026-02-05 更新2026-04-28 收录

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https://figshare.com/articles/dataset/_p_The_top_10_potential_drugs_identified_by_for_Alzheimer_s_disease_p_/31271100 数据链接链接失效反馈

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The top 10 potential drugs identified for Alzheimer’s disease.

针对阿尔茨海默病（Alzheimer’s disease）筛选得到的十大潜在药物

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2026-02-05

BACE1 in complex with 4-(3-(furan-2-carboxamido)phenyl)-1-methyl-5-oxo-4-phenylimidazolidin-2-iminium

BACE1抑制剂设计

阿尔茨海默病药物靶点

BACE1 in complex with 4-(3-(furan-2-carboxamido)phenyl)-1-methyl-5-oxo-4-phenylimidazolidin-2-iminium Descriptor: Beta-secretase 1, L(+)-TARTARIC ACID, N-{3-[(2E,4R)-2-imino-1-methyl-5-oxo-4-phenylimi

Protein Data Bank Japan2024-10-30 更新70

Table 3 in Monoterpene indole alkaloids from Vinca minor L. (Apocynaceae): Identification of new structural scaffold for treatment of Alzheimer's disease

阿尔茨海默病药物靶点

天然药物筛选

Table 3 Biological activities of isolated Vinca minor alkaloids. CompoundIC50 h AChE ± SEM (μM) aIC50 h BuChE ± SEM (μM) aIC50 POP ± SEM (μM) a% inhibition of GSK-3β SEM b ±logBB cPAMPA (P e; 10 6 cm

NIAID Data Ecosystem30

Expedient Synthesis of Furo[2,3-d][1,3]thiazinamines and Pyrano[2,3‑d][1,3]thiazinamines from Enones and Thiourea

杂环化合物合成

阿尔茨海默病药物靶点

Michael addition of thiourea to enones with subsequent intramolecular aminal ether formation provided easy access to furo[2,3-d]thiazinamines and pyrano[2,3-d][1,3]thiazin-2-amines. These amines

Figshare2016-04-11 更新10

Identification of Small Molecule Inhibitors of Amyloid β‑Induced Neuronal Apoptosis Acting through the Imidazoline I 2 Receptor

阿尔茨海默病药物靶点

咪唑啉I2受体靶向

Aberrant activation of signaling pathways plays a pivotal role in central nervous system disorders, such as Alzheimer's disease (AD). Using a combination of virtual screening and experimental testing,

NIAID Data Ecosystem60

Calorimetric Studies of Binary and Ternary Molecular Interactions between Transthyretin, Aβ Peptides, and Small-Molecule Chaperones toward an Alternative Strategy for Alzheimer’s Disease Drug Discovery

阿尔茨海默病药物靶点

蛋白质-肽相互作用热力学

Transthyretin (TTR) modulates the deposition, processing, and toxicity of Abeta (Aβ) peptides. We have shown that this effect is enhanced in mice by treatment with small molecules such as iododiflunis

NIAID Data Ecosystem30

The top 10 potential drugs identified for Alzheimer’s disease.

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