A Highly Efficient and Direct Approach for Synthesis of Enantiopure β-Amino Alcohols by Reductive Cross-Coupling of Chiral <i>N</i>-<i>tert</i>-Butanesulfinyl Imines with Aldehydes

A highly efficient and practical approach for the synthesis of optically pure β-amino alcohols by the SmI2-induced reductive cross-coupling of chiral N-tert-butanesulfinyl imines with aldehydes was developed. This method allows the preparation of a broad range of chiral β-amino alcohols, including functionalized ones under mild conditions. It provides a straightforward access to enantiopure β-amino alcohols that are widely applicable in asymmetric synthesis.