Supplementary Material for: Vastly Different Exercise Programs Similarly Improve Parkinsonian Symptoms: A Randomized Clinical Trial

Objectives: To directly compare the effects of agility exergaming (EXE) and stationary cycling (CYC) exercise training on Parkinson’s disease (PD) patients’ mobility and clinical symptoms. Design: Randomized clinical trial. Setting: Outpatient physiotherapy clinic in a hospital. Participants: Seventy-four stage 2–3, nondemented PD patients were included in this study. Intervention: The groups were as follows: EXE (n = 25), CYC (n = 25), and a wait-listed control group (CON; n = 24). The EXE and CYC groups exercised 5×/week for 5 weeks, matched at 80% of the age-predicted maximal heart rate. Main Outcomes: The primary outcome was the Movement Disorders Society Unified Parkinson’s Disease Rating Scale (UPDRS-II) score. Secondary outcomes were Parkinson’s Disease Quastionnaire-39 (PDQ-39), the Beck Depression Inventory (BDI), the Schwab and England Activities of Daily Living (SE-ADL) scale, Euro-Quality of Life-5 Dimensions (EQ-5D) questionnaire, the Berg Balance Scale (BBS), the Balance Evaluation Systems Test (BESTest), the Tinetti Assessment Tool (TAT), the Dynamic Gait Index, the 6-min walk test (6MWT), and standing posturography. Results: After treatment, UPDRS-II scores improved (mean change: EXE, –4.5 points; CYC, –3.2 points). The results for the other outcomes (EXE and CYC, respectively) were: PDQ, 13 and 17%; BDI, –2.5 and –2.1 points; 6MWT, 129.6 and 141.6 m; and EQ-5D, 12 and 9% (all p p p > 0.05). Conclusion: Two highly different exercise programs resulted in similar improvement of most motor and clinical symptoms in PD patients.研究目的：直接比较敏捷性运动体感游戏（agility exergaming, EXE）与固定式骑行（stationary cycling, CYC）训练对帕金森病（Parkinson’s disease, PD）患者运动能力与临床症状的影响。研究设计：随机对照临床试验。研究场所：某医院门诊物理治疗诊所。研究对象：本研究共纳入74例2~3期无痴呆的帕金森病患者。干预方案：将受试者分为3组：敏捷性运动体感游戏组（EXE组，n=25）、固定式骑行训练组（CYC组，n=25）以及等待列表对照组（CON组，n=24）。EXE组与CYC组每周训练5次，持续5周，训练强度匹配为年龄预测最大心率的80%。主要结局指标：以运动障碍学会统一帕金森病评定量表（Movement Disorders Society Unified Parkinson’s Disease Rating Scale, UPDRS-II）评分为主要结局指标。次要结局指标包括：帕金森病问卷39项（Parkinson’s Disease Questionnaire-39, PDQ-39）、贝克抑郁量表（Beck Depression Inventory, BDI）、施瓦布-英格兰日常生活活动能力（Schwab and England Activities of Daily Living, SE-ADL）量表、欧洲五维健康量表（Euro-Quality of Life-5 Dimensions, EQ-5D）、伯格平衡量表（Berg Balance Scale, BBS）、平衡评估系统测试（Balance Evaluation Systems Test, BESTest）、廷内蒂评估工具（Tinetti Assessment Tool, TAT）、动态步态指数、6分钟步行试验（6-min walk test, 6MWT）以及站立姿势图检测。研究结果：干预后，UPDRS-II评分均得到改善（平均变化值：EXE组减少4.5分，CYC组减少3.2分）。其余结局指标的组间结果（EXE组与CYC组分别对应）如下：PDQ-39评分分别改善13%与17%；BDI评分分别降低2.5分与2.1分；6MWT步行距离分别增加129.6m与141.6m；EQ-5D评分分别改善12%与9%（所有组间比较p>0.05）。研究结论：两种差异显著的运动训练方案均可使帕金森病患者的多数运动与临床症状得到相似程度的改善。