Analgesic effect of simultaneously targeting multiple pain processing brain circuits in an aged humanized mouse model of chronic pain by transcranial focused ultrasound (Ultrasound Characterizations: Ex-vivo Scanning)

We have demonstrated a more accessible, non-invasive transcranial focused ultrasound pain treatment strategy for senior subjects. This approach involves simultaneously targeting multiple pain-processing circuits using a battery-powered, compact, and low-cost ultrasound analog front end.The dataset includes 2 .mat files with formatted transcranial focused ultrasound pressure scanned through hydrophone in the free water and presence of a freshly excised mouse skull sample (3-dimensional variable: <b>Intensity_locations</b>). Each file name is labeled with the scanning scenarios, i.e., free water vs. mouse skull along with custom-built and battery-operated ultrasound analog front end. The spatial step sizes of the 3D matrix (<b>Intensity_locations</b>) are included in each of these files (variables: step for x and y dimensions, slice for z dimension, physical unit: mm). The pulse duration (PD) is 200 micro-second, and center frequency of the transducer is 500 kHz. The variables <b>xaxis_locations, yaxis_locations, </b>and<b> zaxis_locations</b> described the total step/slice numbers along those three directions.This work was supported in part by NIH EB029354, NS124564, NS131069, and HL147562. More information can be found in the corresponding manuscript:Kim MG, Yeh C-Y, Yu K, Li Z, Gupta K, He B. Analgesic effect of simultaneously targeting multiple pain processing brain circuits in an aged humanized mouse model of chronic pain by transcranial focused ultrasound. APL Bioengineering.If anyone uses the whole or part of the dataset provided here, we kindly ask you to cite the above publication in any of your publications or presentations.

本研究针对老年受试者，开发了一种更具易用性的非侵入式经颅聚焦超声（transcranial focused ultrasound）疼痛治疗方案。该方案依托电池供电、体积小巧且成本低廉的超声模拟前端，可同时靶向多条疼痛处理神经环路。本数据集包含2个.mat格式文件，记录了分别在自由水域以及新鲜离体小鼠颅骨样本存在的场景下，通过水听器扫描得到的经颅聚焦超声压力场数据，其三维变量为<b>强度分布位置（Intensity_locations）</b>。每个文件的命名均标注了扫描场景（即自由水域与小鼠颅骨场景），以及本次实验所使用的定制化电池供电超声模拟前端相关信息。上述三维矩阵（<b>Intensity_locations</b>）的空间步长信息均包含在各文件中：x、y维度的步长变量为`step`，z维度的步长变量为`slice`，物理单位为毫米（mm）。超声脉冲的持续时间（PD）为200微秒，换能器的中心频率为500千赫兹（kHz）。变量<b>x轴位置（xaxis_locations）</b>、<b>y轴位置（yaxis_locations）</b>与<b>z轴位置（zaxis_locations）</b>分别对应三个方向上的总步数/切片数。本研究部分受美国国立卫生研究院（NIH）项目EB029354、NS124564、NS131069以及HL147562资助。更多详细信息可参阅相关论文：Kim MG, Yeh C-Y, Yu K, Li Z, Gupta K, He B. 经颅聚焦超声同时靶向慢性疼痛老年人源化小鼠模型的多条疼痛处理脑环路的镇痛效应. APL Bioengineering。若您在研究中全部或部分使用本数据集，请在相关出版物或学术汇报中引用上述论文。