Acute disseminated encephalomyelitis (ADEM) associated with mosquito-borne diseases: Chikungunya virus X yellow fever immunization

Abstract Acute disseminated encephalomyelitis (ADEM) is a demyelinating autoimmune neuropathic condition characterized by extensive bilateral and confluent lesions in the cerebral white matter and cerebellum. The basal ganglia and gray matter may also be involved. In most cases, the symptoms are preceded by viral infection or vaccination. In this report, we present a case of ADEM associated with optic neuritis presenting alongside two potential triggering factors: chikungunya virus infection and yellow fever immunization.

摘要：急性播散性脑脊髓炎（Acute disseminated encephalomyelitis, ADEM）是一类脱髓鞘性自身免疫神经病变，以双侧广泛融合的大脑白质与小脑病变为典型特征，基底神经节及灰质亦可受累。多数病例在发病前存在病毒感染或疫苗接种史。本报告报道1例合并视神经炎的ADEM病例，该病例同时存在两种潜在诱发因素：基孔肯雅病毒感染与黄热病疫苗接种。