Transcriptome analysis of liver from subjects with normal glucose tolerance and steatosis<1 compared to subjects with impaired glucose metabolism and steatosis >3

Liver transcriptome profile in subjects with impaired glucose metabolism and steatosis >3 revealed differences compared with subjects with steatosis <1 and normal glucose tolerance. Several well-characterized markers of non-alcoholic fatty liver disease (NAFLD) were identified as differentially expressed between the two groups. Hepatic transcriptome from subjects with normal glucose tolerance and histological steatosis grade 0-1 (n=3) were compared with subjects with impaired glucose metabolism and steatosis grade >3 (n=3).