Cryo-EM structure of the SARS-CoV-2 S-6P in complex with 35B5 Fab(1 down RBD, state1)

Cryo-EM structure of the SARS-CoV-2 S-6P in complex with 35B5 Fab(1 down RBD, state1) Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of 35B5 Fab, Light chain of 35B5 Fab, ... Authors: Wang, X.F, Zhu, Y.Q. Deposit date: 2021-03-04 Release date: 2022-04-06 Last modified: 2025-07-02 Method: ELECTRON MICROSCOPY (3.69 Å) Cite: A potent human monoclonal antibody with pan-neutralizing activities directly dislocates S trimer of SARS-CoV-2 through binding both up and down forms of RBD Signal Transduct Target Ther, 7, 2022

结合35B5抗原结合片段（Fab）的SARS-CoV-2 S-6P冷冻电镜（Cryo-EM）结构（含1个向下构象受体结合域（Receptor Binding Domain, RBD），状态1）。描述项：2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖、35B5 Fab重链、35B5 Fab轻链……作者：Wang X.F、Zhu Y.Q。提交日期：2021-03-04；发布日期：2022-04-06；最后修改日期：2025-07-02。实验方法：电子显微镜（分辨率3.69 Å）。引用文献：《具有广谱中和活性的强效人源单克隆抗体——通过结合SARS-CoV-2受体结合域的上下两种构象直接解离病毒刺突三聚体》，发表于《信号转导与靶向治疗（Signal Transduct Target Ther）》，2022年，第7卷。