Genome regions showing frameshifts and/or major sequence changes^a (MSC) of <i>T. p. pallidum</i> (SS14, DAL-1 and Mexico A), <i>T. p. pertenue</i> strains (Samoa D, CDC-2 and Gauthier), and the Fribourg-Blanc isolate when compared to the reference Nichols genome.

aMajor sequence changes were defined as continuous amino acid replacements comprising 10 or more residues or 15 and more dispersed amino acid replacements. bThe following algorithms were used for identification of sequence motifs and for prediction of cellular organization: SignalP, LipoP, CDD, Pfam, PSORT, and InterProScan. cThe reference Nichols strain was not resequenced in this region.